TB-500 (Thymosin Beta-4) is a synthetic peptide fragment modeled after a naturally occurring 43-amino-acid protein found in most mammalian cells. It is studied for its potential to support tissue regeneration, angiogenesis, and cellular migration in muscle, tendon, nerve, and organ models.

Key Research Features

• Compound: Thymosin Beta-4 (TB-500)
• Class: Regenerative and cytoskeletal-modulating peptide
• Primary focus: Tissue repair, angiogenesis, cellular migration, inflammation models
• Form: Lyophilized peptide powder for reconstitution
• Concentration: 5 mg per vial

Research Background

TB-500 has been explored for its ability to regulate actin binding and cellular motility, critical processes in tissue repair and regeneration. Pre-clinical literature suggests TB-500 influences endothelial cell differentiation, angiogenesis, and collagen deposition, potentially enhancing repair in muscle, cardiac, and dermal models.

Notable Research Highlights

• Cardiac regeneration: TB-500 was shown to support vascular growth and myocardial recovery post-injury (Ann. N.Y. Acad. Sci., 2010).
• Cystic fibrosis studies: Combined with dornase alfa, TB-500 improved mucus transport and sputum fluidity (dose-dependent response).
• Muscle regeneration: Elevated TB-500 expression observed following injury, promoting myoblast migration and muscle fiber repair.

Mechanism of Action

• Promotes angiogenesis (formation of new blood vessels)
• Stimulates myocyte and keratinocyte migration
• Encourages collagen deposition and ECM remodeling
• Modulates inflammatory response to support repair

Reference Sampling & Dosing Protocol (Educational)

Protocols are provided for educational and laboratory modeling purposes only. All concentrations assume reconstitution with 1 mL bacteriostatic water per 5 mg vial (yielding 5 mg/mL).

Reference Notes

• Reconstitution: Add 1 mL bacteriostatic water to 5 mg vial → 5 mg/mL solution.
• Measurement: 1 unit (0.01 mL) ≈ 0.05 mg.
• Storage: Keep lyophilized powder in a cool, dark environment. Refrigerate reconstituted peptide at 2–8 °C.
• Injection type: Subcutaneous, as per study design.

Expected Research Observations

• Improved angiogenic response in tissue models
• Accelerated skeletal and cardiac muscle repair
• Reduction in localized inflammation
• Enhanced connective tissue elasticity and mobility post-injury

All outcomes derived from pre-clinical and in-vitro models. Not indicative of clinical efficacy or approved therapeutic use.

Handling & Stability

• Lyophilized: Store in a cool, dry location below 25 °C.
• Reconstituted: Refrigerate at 2–8 °C for up to 14 days; do not freeze.
• Light sensitivity: Protect from UV exposure.

What’s in the Box

• 1 × 5 mg TB-500 (Thymosin Beta-4) lyophilized vial
• 1 × 2 mL bacteriostatic water vial for reconstitution

Why Choose EU Pharmaceuticals?

EU Pharmaceuticals peptides are HPLC-verified for purity and identity, manufactured under strict research-grade quality control. Each vial provides consistent concentration accuracy suitable for academic, biochemical, and pre-clinical applications.

For laboratory, educational, and research use only. Not for human or veterinary ingestion or therapeutic use. No medical or performance claims are made or implied. Buyer assumes responsibility for lawful handling and compliance.