Letrozole 2.5 mg is a third-generation non-steroidal aromatase inhibitor investigated for its ability to suppress estrogen biosynthesis in endocrine models. Research has shown estrogen reductions of approximately 96 – 98 % in controlled settings. In addition, Letrozole may influence luteinizing hormone (LH), follicle-stimulating hormone (FSH), and sex-hormone-binding globulin (SHBG) activity, making it a frequent inclusion in studies of hormonal regulation and estrogen-dependent pathways.

Pre-clinical studies have also explored its potential to modulate gynecomastia-related mechanisms, though findings remain limited to non-therapeutic research contexts.

Mechanism of Interest

• Acts by blocking the aromatase enzyme responsible for converting androgens into estrogens.
• Results in measurable decreases in circulating estradiol levels.
• May elevate LH, FSH, and SHBG concentrations in laboratory hormone assays.
• Supports endocrine models examining estrogenic suppression and feedback dynamics.

Pharmacological Profile (Reference Data)

• Half-life: Approximately 2 – 4 days (long steady-state build-up)
• Steady-state achievement: ≈ 60 days of continuous exposure in modeled kinetics
• Elimination route: Primarily hepatic / renal metabolism

Laboratory Dosage Reference

Concentrations below represent the most commonly referenced ranges in assay and suppression studies. These are not medical or therapeutic guidelines but serve as concentration standards for comparative testing.

Comparative Research Notes

• Letrozole shows stronger aromatase inhibition than Arimidex (Anastrozole) in most trials.
• May reduce HDL cholesterol in long-term metabolic observations.
• Estrogen rebound following discontinuation is a known study variable.
• Alternative compounds (e.g., Arimidex ) are sometimes used when gentler modulation is desired.

Product Information

• Form: Oral tablet
• Strength: 2.5 mg per tablet
• Quantity: 28 purple tablets per box

Storage

• Store in a cool, dry environment below 25 °C.
• Protect from light and moisture; keep sealed until analysis.

Why Choose EU Pharmaceuticals?

EU Pharmaceuticals produces laboratory-grade reference compounds under stringent quality standards. Every batch is identity-verified and purity-tested to ensure accurate, reproducible data in research applications.

For laboratory, educational, and research use only. Not intended for human or veterinary administration, ingestion, or therapeutic purposes. No medical or performance claims are made or implied. Purchasers are responsible for lawful handling and storage in accordance with applicable regulations.